Each 100 gm contains:
Metronidazole 20 gm
Amoxicillin (as trihydrate ) 10 gm

Vaxflagy is a combined antibacterials containing amoxicillin and metronidazole. Amoxicillin is a beta-lactam antibiotic and its structure contains the beta-lactam ring and thiazolidine ring common to all penicillins.It prevents the bacterial cell wall from forming by interfering with the final stage of peptidoglycan synthesis. It inhibits the activity of transpeptidase enzymes which catalyse cross linkage of the glycopeptides polymer units that form the cell wall.It exerts a bactericidal action but causes lysis of growing cells only. It can be referred to as a time dependent antibiotic. It is active against some Gram negative bacteria and most Gram positive bacteria as Penicillin sensitive pasteurella spp., Proteus spp., Streptococcus spp., E.coli and Gram positive cocci. Metronidazole is a concentration dependent bactericidal agent against susceptible bacteria. Its exact mechanism of action is taken up by anaerobic organisms where it is reduced to an unidentified polar compound. It is believed that this compound is responsible for the drug’s antimicrobial activity by disrupting DNA and nucleic acid synthesis in the bacteria. It has activity against most obligate anaerobes including Bacteroides spp. (including B. fragilis), Fusobacterium veillonella, Clostridium spp., Peptococcus spp.and Peptostreptococcus spp. Actinomyces is frequently resistant to metronidazole. Some isolates of C.difficile may be resistant. Metronidazole is is also trichomonacidal and amebicidal in action and acts as a direct amebicide. It has therapeutic activity against Entamoeba histolytica, Trichomonas spp., Giardia spp. and Balantidium coli. It acts primarily against the trophozoite forms of Entamoeba rather than encysted forms.Target species: Poultry – Dogs – Cats

For the treatment of:
•Giardiosis caused by Giardia duodenalis.
•Rhinitis caused by Pasteurella spp. and Streptococcus spp.
• Bronchopneumonia caused by Pasteurella spp., Escherichia coli and Gram- positive cocci.
•Pyelonephritis and infections of the lower urinary tract caused by Escherichia coli, Proteus spp. and Gram-positive cocci.
•Endometritis caused by Escherichia coli, Streptococcus canis and Proteus spp.
•Local skin infections caused by Streptococcus spp.

Route of administration: Taken orally via drinking water
For whole product: 1 gm of product / 10 kg b.wt . twice daily for a minimum of 5 consecutive days . the majority of routine cases respond after between 5 and 7 days of therapy . if no improvement is observed after 5- 7 days, the diagnosis should be re-assessed . in chronic or refractory cases .a longer course of therapy may be required.

Store at a temperature not exceeding 30°C in a dry place, used immediately after opening and reconstitution

500 gm